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Building new synthetic strategies for indazoles is actually a popular subject matter in modern analysis. The changeover-steel-catalyzed C–H activation/annulation sequence has arisen as a favorable tool to build functionalized indazole derivatives with enhanced tolerance in medicinal applications, useful flexibility, and structural complexity. In
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A zebrafish animal design is used to perform a comparative investigation in the metabolites and biotransformation pathways of fentanyl while in the zebrafish’s liver and brain, and it is proposed the metabolites M1 (normetabolite) and M3-b (monohydroxylation) could serve as indicators of fentanyl metabolism within the brain.لدينا أيضًا